glutathione variegate porphyria

glutathione variegate porphyria with coexistent decrease in porphobilinogen deaminase activity mRNA-based therapy in a rabbit

Name: glutathione variegate porphyria with coexistent decrease in porphobilinogen deaminase activity mRNA-based therapy in a rabbit
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mRNA based therapy in a rabbit model of variegate porphyria offers new insights into the pathogenesis of acute attacks: Molecular Therapy Nucleic Acids Photomutilation in Homozygous Variegate Porphyria Porphyria for Patients Porphyrin Induced Protein Oxidation and Aggregation as a Mechanism of Porphyria Associated Cell Injury Cellular and Molecular Gastroenterology and Hepatology Porphyrias Springer Nature Link

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4a, b, c)

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In regard to eNOS function, 5-methyltetrahydrofolate (MTHF), the active form of folic acid, does not have an effect on pterin-free eNOS, but directly interferes with BH 4 -repleted, partially uncoupled eNOS, shifting it from superoxide production toward NO production (Stroes et al., 2000)