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Li H, Salehjahromi M, Godoy MCB, Qin K, Plummer CM, Zhang Z, Hong L, Heeke S, Le X, Vokes N, Zhang B, Araujo HA, Altan M, Wu CC, Antonoff MB , Ostrin EJ, Gibbons DL, Heymach JV, Lee JJ, Gerber DE, Wu J, Zhang J

Therapeutic Index: A measure of the margin of safety for a drug Ratio of LD50(dose that is lethal in 50% of population) and ED50 (dose that is effective in 50%)

Graphical Abstract 1 Introduction Bioactive compounds in food refers to substances that confer additional benefits beyond their nutritional value

The secondary outcome measurements were improvement of neurologic symptoms and hematologic findings (serum folate, homocysteine, ferritin, iron, total iron binding capacity, transferrin, and mean corpuscular volume)