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Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2)

Patients in STEP 1 were desirous of weight loss as a reason for study participation and received structured lifestyle intervention (which included a 500 kcal per day diet with 150 min per week of physical activity)

Neurons presented with severe damage

By further comparing the gene expression profiles of the proline-treated group, the model group, and the control group from the above RNA-seq data, we obtained 4 DEGs, namely C-X-C Motif Chemokine Ligand 9 (Cxcl9), Z-DNA Binding Protein 1 (Zbp1), the 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (HMGCS2), and Azgp1 (Fig