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The second key strategy was the overproduction of CgCS and CitS

This change is congruent with our observations showing the largest change in curvature realized toward the end of therapy

88 In these experiments, we identified a window where drug metabolism and NAPQI formation were completed, but GSH could still effectively protect due to its scavenging of peroxynitrite, suggesting that this oxidant is critical for APAP-induced liver injury