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Treatment with pramipexole and ropinirole (in combination with levodopa-carbidopa) for 14 days significantly reduced small intestinal motility, increased bacterial overgrowth in the distal small intestine, increased bacterial richness in the jejunum (not the ileum), and had a significant effect on -diversity in both proximal small intestine and ileum, with Muribaculaceae and Lactobacillus mostly contributing to the variation [73]

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Biosynthesis As an essential amino acid, lysine is not synthesized in animals, hence it must be ingested as lysine or lysine-containing proteins