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Pu MJ, Yao CJ, Liu LM, Ren LJ, Li YL, Xie Y

5154 Mutant mice harboring NIK gene deletion or expressing a non-processible p100 displays impaired generation of Th1 and Th17 subsets of CD4 + effector T cells

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ROS also has a critical role in myelin phagocytosis and it has been observed that using ROS inhibitors like NADPH oxidase inhibitors, lipoic acid or catalase enzyme reduced myelin phagocytosis by macrophages [6]