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Potential regulators of the senescence-associated secretory phenotype during senescence and ageing

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The c-Abl kinase blocker imatinib, while technically a small-molecule, has inspired development of a recombinant fusion protein that sequesters extracellular c-Abl ligands, aiming to shield oocytes from TAp63-mediated apoptosis

160,161 The antitumoral effect of a low-protein diet also hinges on promoting immunosurveillance against cancer, while the dietary restriction of amino acids may adversely affect the metabolic reprogramming of the TME in various ways