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Or, more specifically, how one of these enzymes starts to fail with age or persistent illness

B.TerrinG.ElceA.PezzellaV.Heinz-ErianP.PedrolliA.et al (2013)

Exogenous GABA promotes drought-resistance in plants

This dependence may allow fine-tuned turnover of numerous substrates involved in cell-cycle control, nuclear factor-B (NF-B) activation, DNA damage response, autophagy and mitophagy 59,60,61,62,63