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Finally, it is important to mention that the beneficial effect of VPA on women of childbearing years should be reassessed as a result of teratogenicity reported during pregnancy [163]

2, rational engineering of nanomedicines that precisely target glucose metabolism, which includes glucose supply, glucose depletion, modulation of glycolytic enzymes, and simultaneously blocking oxidative phosphorylation and glycolysis, represents a promising therapeutic paradigm to disrupt tumor bioenergetics and halt malignant progression [55, 56]

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For Evotip loading, any remaining beads were removed by plate-based filtration (Merck, 10448023), and half the filtered digest volume was loaded on Evotips according to the manufacturers instructions