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Endoxifen, the most potent metabolite is produced via N - demethylation of tamoxifen to form N -desmethyltamoxifen (NDM) whereas CYP2D6 catalyzed 4-hydroxylation of NDM to form endoxifen

As ferroptosis is recognized as a type of autophagy-dependent cell death, we tested whether the knockdown of ATG5 or Beclin1 affected 3-BP/cetuximab-induced ferroptosis