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Ceelen W

DEMETER2 (for RNAi) and CERES (for CRISPR) scores express how lethal is a knockdown or knockout, with highly negative values indicating stronger dependency of that gene

A reverse effect was observed with Cd and Pb in some plants

THOC2 and THOC5 sustain the export and expression of pluripotency gene transcripts, thereby governing embryonic stem cell self-renewal and differentiation 53 , while THOC1 or THOC5 depletion led to the inhibition of ISC proliferation and the impairment of the gut epithelial barrier 54,55