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doi: 10.1089/scd.2017.0123 60 XiongYZhangYXiongSWilliams-VillaloboAE

In addition, ongoing research implicates diseases such as obesity, heart disease, and diabetes

Thus, aging and various pathological conditions and human diseases, especially neurodegenerative diseases, are caused by biochemical changes in these macromolecular components, ultimately causing oxidative damage (78)

Presently, over 20 nanomedicines have received clinical therapeutic or diagnostic approval from the FDA or the European Medicines Agency (EMA), and an additional 75 clinical trials examining nanoparticles have been initiated in recent years [188]