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Consequently, the development of agents with high CNS bioavailability, selective target engagement, and minimal adverse effects, confirmed by well-powered, stage-stratified clinical trials, will therefore be necessary to determine their clinical utility, even though inducers and NLRP3 inhibitors continue to be promising candidates for disease-modifying therapy

Lung function phenotypes can neither distinguish between obstruction in the small airways and emphysematous destruction of the lung parenchyma nor provide information about regional differences in disease severity

Pharmacists have consistently demonstrated our commitment to public health, and we should be very proud of that, Wigston says