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Science 375:12541261 Song MO, Li J, Freedman JH (2009) Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper

No significant differences in hematological or serum biochemical parameters were observed between any treatment group and the control group (Additional file 2: Tables S8S9)

One interesting feature of MOTS-c biology is that MOTS-c seems to travel to the nucleus of cells under conditions of stress and alter the expression of nuclear genes that control antioxidant defences as well as metabolic programs