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doi: 10.1016/j.coi.2017.07.007 2 RendonASchakelK

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Human dorsal root ganglia

Reports suggest that elevated VEGF within the TME is sensed by VEGFR-2 on TAMS which induces Akt/mTOR signaling ultimately leading to induction of VEGF secretion [101,105], thus resulting in a positive feedback mechanism involving Nrf2-mediated induction of EMT in CCs [101]