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Polyunsaturated fatty acids (PUFAs) have been shown to reduce hepatic triglyceride accumulation, while diets high in the n-6/n-3 PUFA ratio and low in total PUFA content are linked to the development of fatty liver and other chronic metabolic disorders [75, 76]

Interestingly, the study also showed that cytokine production in human lung slices and human BAL fluid from in vivo studies after treatment with LPS are correlated (58), reinforcing the applicability of PCLS in investigating the molecular pathways of pulmonary inflammation