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Evaluation of the Effects of Quercetin on Damaged Salivary Secretion

According to the World Health Organization (WHO), 99% of the global population breathes polluted air, and low- and middle-income countries are at a greater risk of suffering from the highest exposure ( Studies have demonstrated that particulate matter (PM) pollution leads to increased prevalence, emergency room visits, hospitalization, and mortality due to asthma, chronic obstructive pulmonary disease (COPD), lower respiratory tract infections, and lung cancer ( 2.5 ) and ultrafine particles (UFP) (diameter 0.1m) can penetrate deeper into the lung to terminal bronchioles even into the alveoli ( The airway epithelium is the first barrier against inhaled toxins and particles

Hsu PH, Chen YH, Huang PI, Hwang PA

Although the combination of atezolizumab and PEGPH20 failed to achieve the primary endpoint of improved objective response rate (ORR) compared to chemotherapy regimens in both studies, the signal-seeking trial design accelerated proof-of-concept evaluation while minimizing patient exposure to suboptimal therapies