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The Croatian Phase I and II clinical trials for inflammatory bowel disease conducted in the 1990s by pharmaceutical company Pliva claimed safety with no significant toxicity, though complete peer-reviewed data never appeared in scientific literature beyond conference abstracts

In contrast, total drug concentration will increase less rapidly than the dosing rate would suggest as protein binding approaches saturation at higher concentrations

Hormonal acne is linked to changes in your hormonal levels (such as during puberty, pregnancy, and menstruation)

Nausea and diarrhea rates are comparable between the two compounds