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B, adapted from Sarkadi B, Homolya L, Szakcs G, et al: Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system, Physiol Rev 86:1179-1236, 2006.) Drug binding occurs within the plasma membrane near the cytoplasmic surface, limiting transport to drugs with good lipid solubility or sufficient length to reach the active site