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Epigenetic mechanisms for nutrition determinants of later health outcomes

Glossary 5-mC 5-methylcytosine AD alcohol dependence AHCY SAH hydrolase AIE adolescent intermittent ethanol ALD alcohol-induced liver disease ALKBH5 AlkB homolog 5 ARC activity-regulated cytoskeleton associated protein AUD alcohol use disorder BDNF brain-derived neurotrophic factor CRE cAMP response element DA dopamine dlPFC dorsolateral prefrontal cortex DNMT DNA methyltransferase DYN dynorphin EOS endogenous opioid system eRNA enhancer RNA EZH2 enhancer of zeste homolog 2 FTO fat mass and obesity-associated protein GABA gamma-aminobutyric acid GR glucocorticoid receptor KDM lysine demethylase KMT lysine methyltransferase M6A N6-methyladenosine METTL14 methyltransferase-like 14 METTL3 methyltransferase-like 3 mPFC medial prefrontal cortex MS methionine synthase NAc nucleus accumbens NMDA N-methyl-D-aspartate NOC nociceptin NPY neuropeptide Y SAH S-adenosylhomocysteine SAM S-adenosylmethionine SARE synaptic activity response element SNP single nucleotide polymorphism WTAP Wilms tumor 1-associating protein YTHDF YT521-B homology domain family References 1

Funding This research was supported by a grant of Korean ARPA-H Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: RS-2024-00507256)

Chemistry of Quercetin In plants, quercetin is produced from the phenylpropanoid pathway and is ultimately derived from phenylalanine