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WE-EF-BRA-05: Experimental Design for High-Throughput In-Vitro RBE Measurements Using Protons, Helium and Carbon Ions

10.1046/j.0953-816x.2001.01691.x Eur

Notably, the accumulation of genetic mutations (e.g., point mutations, inversions, translocations, deletions, and polyploidy) drives the malignant transformation of cancer cells and facilitates the acquisition of cancer-specific hallmarks, including cell immortality, apoptosis inhibition, drug resistance, angiogenesis, invasiveness, and the activation of metastatic processes [3,4,5,6]

[55] Recent studies have found that the inhibition of certain miRNA types is able to effectively eliminate senescent cells in vitro , suggesting that miRNAs may indeed have a causal role in senescence