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In contrast, high levels of NO binds ferric and ferrous forms of MPO to form the corresponding stable six-coordinated low spin, MPO-Fe(III)-NO and Fe(II)-NO complex, respectively, rendering them catalytically inactive [52]

Despite this, the CD38 expression on activated NK cells is not altered by Lenalidomide treatment despite a similar reduction in Ikaros, indicating that this process is specific to MM cells compared to immune cells [100]