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Second, the development of new drugs requires additional and more detailed preclinical and clinical studies to determine whether long-term use is biotoxic, whether the drug has adverse effects on other peripheral organs or whether the drug candidate has a real therapeutic effect on the patients

Blood-brain barrier dysfunction in multiple sclerosis: causes, consequences, and potential effects of therapies

doi: 10.3389/fcell.2022.841831 Received 22 December 2021 Accepted 09 February 2022 Published 11 March 2022 Volume 10 - 2022 Edited by Chisa Shukunami, Hiroshima University, Japan Reviewed by Petra Kraus, Clarkson University, United States Danny Chan, The University of Hong Kong, Hong Kong SAR, China Updates Copyright 2022 Hickman, Rathan-Kumar and Peck

Pregnancy and breastfeeding no data exist, and apoptosis-inducing agents are a clear unknown