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In PD mice, both intravenous and intranasal Pu-Exos-PR markedly improve motor and non-motor symptomsincluding spontaneous activity, motor coordination, and depressive-like behaviorwhile reducing dopaminergic neuron degeneration, increasing Nissl body density, and enhancing TH expression, indicative of improved neuronal function

Study on bovine GPx1 revealed that only two GSH molecules could bind to each tetramer, indicating that the GSH binding site were formed by residues at least from two subunits 20