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Resting T-cell lysosomes and endosomes contain C3, and its cleavage by the CTSL to generate tonic intracellular C3a is critical in maintaining homeostatic T-cell survival

Pregnant and breastfeeding women should completely avoid high-dose antioxidants unless explicitly directed by their obstetrician

To hinder the host translation process, nsp1 is proposed to function by two mechanisms: the first is to bind the ribosomal 40S subunit during the initiation stage 64 and the second is to induce host mRNA degradation 65

Proteostasis resilience: a systems-level perspective Together, these functional, spatial and adaptive properties define what can be conceptualized as proteostasis resilience, the capacity of cells, tissues and organisms to sustain proteome integrity despite acute or chronic stress