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As autophagy mediates a non-bacteriolytic mechanism of restriction, these findings align with the findings on an inflammasome-independent mechanism of restriction and demonstrate that host GSH is required for R

SlyA, a transcriptional regulator of salmonella typhimurium , is required for resistance to oxidative stress and is expressed in the intracellular environment of macrophages

The dosing regimen varies depending on whether neurological symptoms are present: With neurological involvement: 1 mg intramuscularly on alternate days until no further improvement, then 1 mg every 2 months [3] [4] Without neurological involvement: 1 mg intramuscularly three times a week for 2 weeks, then 1 mg every 2-3 months for maintenance [3] [4] There is some evidence that high-dose oral B12 (1000-2000 micrograms daily) may be effective even in some malabsorption conditions, though UK practice still generally favours intramuscular treatment in these cases