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Thus, integrins are conduits that convert signals from the ECM environment (rigidity, elasticity and topology) into intracellular biochemical signals that affect cytoskeleton organization, gene expression, and proliferation (Kechagia et al., 2019)

Secondly we compared the metabolic profiles of the gdh3 / gdh3 mutant and wild type when grown in arginine and proline media ( gdh3 -P vs WT-P, gdh3 -R vs WT-R)