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292,542 Ponesimod, a selective S1PR1 agonist for oral use, demonstrated good efficacy in a phase II clinical trial, where 46.0% of patients on ponesimod at 20 mg once daily achieved PASI 75 response at week 16, 48.1% of patients on ponesimod at 40 mg once daily achieved this goal, and the percentage was only 13.4% in patients on placebo