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However, the activation of STAT3 signaling stimulates a negative feedback response through the induction of SOCS factors which not only inhibit the activity of insulin/IGF-1 receptors but also that of many cytokine receptors

Naumov GN, Nilsson MB, Cascone T, Briggs A, Straume O, Akslen LA, Lifshits E, Byers LA, Xu L, Wu HK, Jnne P, Kobayashi S, Halmos B, Tenen D, Tang XM, Engelman J, Yeap B, Folkman J, Johnson BE, Heymach JV

Despite these findings, the specific mentalization impairments characterizing psychotic illnesses remain empirically unexplored (Brent et al., Indirect Evidence in Childhood for an Early Association Between Mentalizing Impairments and Vulnerability to Psychosis Mentalizing deficits have been characterized as trans-diagnostic (Fonagy et al., 2011), yet it remains unclear whether specific mentalizing deficits can be identified along the different stages of psychotic expression

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