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Zhu Z, Hu R, Li J et al (2021) Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis

Specifically, GCLC directly interacts with SIRT2, which can be substantially enhanced upon ROS treatment

Critical role of reactive nitrogen species in lung ischemia-reperfusion injury

Howsoever, the synthesis of 3-HK from Kyn by the flavoprotein kynurenine-3-monoxygenase (KMO) is another critical point in the Kyn pathway, determining the balance between the neurotoxic component 3-HK and the neuroprotective KYNA [216]