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As of mid-2026, neither cagrilintide nor retatrutide is approved by the FDA or EMA for any indication

These sample sizes cannot detect modest effects or uncommon harms

eLife 7 , e33246 (2018)

406 Therefore, endogenous GLP-1R signaling in astrocytes plays a critical role in maintaining mitochondrial homeostasis and is dependent on FGF21 to effectively regulate glucose metabolism