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Pb may hinder Munc13-mediated priming by disturbing upstream signaling cascades that regulate its activity (e.g., via DAG or PKC) [106], while reduced expression of SNAP-25 observed in some neurotoxicant models may compromise SNARE complex assembly and vesicle fusion [68]

For the analysis of lipids in the serum from WT, Gclc L-KO, Nrf2 L-KO, and L-DKO mice, the methods were the same with the following exceptions: MS2 scan conditions were applied in positive mode, the scan range was from m/z 120-1000, and the resolution was 120,000 for MS

The histopathological hallmarks of ALD include steatosis, hepatocyte ballooning, and neutrophil infiltration (Stickel et al., 2017), mirrored biochemically by elevated serum transaminases, dyslipidemia, diminished antioxidant enzyme activities, and increased pro-inflammatory cytokines (Wang et al., 2010)