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As this molecule is also associated with activation of CD4 cellsincluding effector cells [96], functional demonstration of regulatory properties would be needed to define their nature

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VEGFAinduced CNV is promoted by NLRP3 inflammasomemediated IL1 activation In contrast to acute laser injury models of neovascular AMD (He & Marneros, 2013), VEGFA hyper mice allow us to investigate which molecular mechanisms do not only contribute to CNV lesion growth (measuring CNV lesion size), but also contribute to their spontaneous agedependent induction without experimental injury (measuring CNV lesion numbers)