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bioRxiv 10.1101/2020.02.20.958579

Biswas S, Hwang JW, Kirkham PA, Rahman I

Additionally, butyrate regulates gut immune cell function by inhibiting histone deacetylase (HDAC) activity, promoting the differentiation of Treg, and suppressing the release of pro-inflammatory cytokines such as IL-6 and TNF-, thereby alleviating intestinal inflammation [439, 440]

IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication