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Transcriptomic profiling reveals AKR1C1 and AKR1C3 mediate cisplatin resistance in signet ring cell gastric carcinoma via autophagic cell death

Notably, the overexpression of CBS nearly restored the growth impairment seen in DDX3X-knockdown cells, while GCLC overexpression had a less pronounced effect on the proliferation of DDX3X-deficient cells (Fig