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In terms of bilirubins effects on immune cells, a 2017 study showed (139) that unconjugated bilirubin upregulates CD39 and thus inhibits Th17 immunoreactivity, this promotes several cancers, such as breast, colorectal, and ovarian cancers (140142), and thus, the inhibition of TH17 by unconjugated bilirubin can play a role in inhibiting related cancer effects

The Association between phosphorylated neurofilament heavy chain (pNF-H) and small fiber neuropathy (SFN) in patients with impaired glucose tolerance

Recent research suggests that factors that modify the above mechanisms, e.g., obesity and Western diet, also alter gut microbiota, degrade the integrity of the gut protective barrier, and expose colonocytes to toxins

These risks will be thoroughly discussed during your consultation appointment