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2.3 Risk assessment of bias Two researchers used the Cochrane collaborations risk of bias tool to determine the bias risk of all included randomized controlled trials ( 2.4 Assessment of evidence quality The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to evaluate the quality or certainty of each compared evidence ( 2.5 Outcome The changes in pain and neuropathic symptoms were our primary measures of concern, but all outcome measures are summarized for each study due to variations in outcome measures among RCTs

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