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The present study determined the effectiveness of L-citrulline and/or GSH on markers indicative of NO synthesis in in vivo conditions with rodents and humans and also in an in vitro condition

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Significance of ferroptosis in glioblastoma Ferroptosis holds uniquely actionable relevance in glioblastoma due to its intersection with glioblastoma-specific metabolic dependencies, therapy resistance, and immunologic constraints that distinguish it starkly from its role in other tumor types

This is in contrast to our observation that the overall level of S6, similarly to GRP78, was not affected by MVI depletion (Figure 6C)