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Iron chelators such as deferoxamine (DFO), deferiprone, and ciclopirox chelate iron and prevent the propagation of lipid peroxidation by limiting the Fenton reaction [17]

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Accordingly, the lack of effect of the dose of D-cysteine used in this study (250 mol/kg, = 30.3 mg/kg per each injection) may be because it does not enter brain cells involved in establishing physical dependence to morphine in sufficient quantities to exert meaningful cell-signaling events that can countermand the processes underlying the development of dependence