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Knowledge about cerebrovascular involvement in neurological disorders is rapidly expanding, and increasing evidence indicates that defects in angiogenesis, and the bloodbrain boundary are causally related to the cognitive dysfunctions that may be found in the course of neurodegenerative disorders (Nicolakakis and Hamel 2011

When blood glucose drops below normal levels (typically below 4.0 mmol/L), the body releases adrenaline as a counter-regulatory response, which can cause tremor, sweating, palpitations, and a jittery feeling

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The driving force behind this combination is the hypothesis of synergy