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PubMed , Journal of Chromatography B , vol

Understanding your options and what to expect Delivery timing and how the process works General questions before you decide Table of Contents Understanding Vitamin B12 and Its Role in Mental Health Vitamin B12 (cobalamin) is an essential water-soluble vitamin that plays a crucial role in numerous physiological processes, including DNA synthesis, red blood cell formation, and neurological function

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For example, one study conducted by Vogiatzoglou and colleagues shows that, when tHcy and MMA reached their breakpoints of 334 and 393 pmol/L respectively as defined as B12 replete, the B12 levels were 400 pmol/L.8 Another study by Selhub and colleagues shows similar results and suggests that tHcy and MMA, as metabolic markers, may replace or augment B12 level in the diagnosis of B12 deficiency.5 In a clinical trial of determining the relationship between the treatment effect and tHcy levels on brain atrophy over 2 years, half of the participants were treated with B12, B6 and folic acid to lower their tHcy levels.9 Results showed that brain atrophy was slowed by 30% compared to placebo, tHcy was lower by 30%, and plasma B12 was raised from 330 to 672 pmol/L