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the present inventors recognize a solution to prevent in vivo target protein cleavage using split-inteins whose catalytic residues are split between two peptide chains: the N-terminal intein (IN) and the C-terminal intein (IC)

Sachs J, Dhl K, Weber A et al (2019) Novel 3,4-dihydroisocoumarins inhibit human P-gp and BCRP in multidrug resistant tumors and demonstrate substrate inhibition of yeast Pdr5