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Catalase, a remarkable enzyme: Targeting the oldest antioxidant enzyme to find a new cancer treatment approach

a Each test incidence is based on the number of patients who had both baseline and at least one on-study laboratory measurement available: pemetrexed /pembrolizumab/platinum chemotherapy (range: 381 to 401 patients) and placebo/pemetrexed/platinum chemotherapy (range: 184 to 197 patients)

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This invention provides methods for generating variant antigen binding sites, e.g., antibodies and specific domains or fragments of antibodies (e.g., Fab or Fc domains), by altering template nucleic acids including by saturation mutagenesis, synthetic ligation reassembly, or a combination thereof