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Funding This research was supported by the National Natural Science Foundation of China (82372618, 82573843, 82302918, 82273287, 82403142, 82404671)

PAMORAs, such as methylnaltrexone, naldemedine, and naloxegol 36,37,38 , can effectively alleviate opioid-induced constipation by selectively blocking MORs in the enteric nervous system without affecting central opioid analgesia 10,21

Regular maintenance sessions are necessary to sustain the effects, with the frequency customised based on individual needs and how well the treatment works [4]