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[2] This is the highest tier of evidence in this entire comparison: randomized, blinded, placebo-controlled, with a hard imaging endpoint (visceral fat measured by CT), replicated across two trials, and reviewed by a regulator

Nevertheless, a European guideline recommends that eGFR should be monitored in at least 3-month intervals in children with CKD started on rhGH treatment, and that treatment should be discontinued in patients presenting with an unexplained decline in eGFR [154]