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In the early stage of the disease, mitophagy mostly acts as an adaptive compensatory mechanism to play a protective role, while with the progression of the disease to the late stage, the regulatory mechanism of mitophagy is disrupted, often showing a state of excessive activation, thereby aggravating tissue damage

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Jiao Y, Wang H, Zhu M, Liu T, Li Y, Yang S, Zhang M, Zhang L (2025) Copper-induced cell death mechanisms and their role in the tumor microenvironment