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k , Frequency of peritoneal (left), intestinal mast cells (centre), and blood basophils (right) by flow cytometry on d16 from control WT or het/mut RMB mice after 3 doses of diphtheria toxin (DT) on days 0, 2, and 4 (n = 6-7 WT and 5-12 RMB het/mut per group)

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Although there are toxic effects of A on oligodendrocytes, clinical trials that have aimed to remove the A plaque in symptomatic AD patients, did not prevent the progressive neurodegeneration and cognitive decline in AD patients [39, 72]