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Additionally, we decided to evaluate the activity of a synthetic analogue of the LL-37 peptide, namely the WLBU2 peptide (RRWVRRVRRWVRRVVRVVRRWVRR), consisting mainly of Arg (13 residues) and Val (8 residues), with 3 Trp residues on the hydrophobic side, separated by at least 7 amino acids to optimize its activity in blood (Deslouches et al., 2005), and the VFR12 (VFRLKKWIQKVI) peptide, which is derived from thrombin, taking into account the fact that coagulation disorders occur in sepsis (Kasetty et al., 2011) and it can be assumed that its concentration increases with sepsis development

Researchers believe, however, that there is a connection between the two, even if they do not know exactly how

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"Best" is not established, because head-to-head human data does not exist