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Acidic (B) and basic (C) elution buffers disrupt this interaction by changing protein charge, whereas in high ionic strength buffers (C) the salt screens the interaction between the two proteins

References: Hammer H et al (2015): A Multifaceted GABA A Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude)

It is then able to be absorbed in the ileum

Here, to decipher the underlying mechanisms, we determined cryo-electron microscopy structures of human VKGC in unbound form, with KH 2 and four haemostatic and non-haemostatic proteins possessing propeptides and glutamate-rich domains in different carboxylation states