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Description

Diagnostics (basel) 14:1100 Fromen CA, Rahhal TB, Robbins GR, Kai MP, Shen TW, Luft JC, Desimone JM (2016) Nanoparticle surface charge impacts distribution, uptake and lymph node trafficking by pulmonary antigen-presenting cells

Figure 1 Cytochrome P450-Mediated Metabolic Activation APAP metabolic activation is mainly catalyzed by the cytochrome P450 enzyme and the reactive metabolite associated with hepatotoxicity is commonly considered to be NAPQI (Streeter et al., 1984)